High Science HDL Forum

High Science HDL FORUM

Mission Area objectives

• Discuss current advances in the science of high-density lipoprotein (HDL), including limitations of HDL as a biomarker, HDL dysfunction, and genetic associations of HDL lipoproteins with atherosclerotic cardiovascular disease.
• Review clinical trial data in HDL genetics and therapeutic targets, such as cholesteryl ester transfer protein.
• Apply pharmacogenomics as a strategy for targeting HDL therapeutics, as well as their potential role in the treatment framework.

TMA Program

• TMA developed a complete Mission Area to help redefine the pros and cons of the role of HDL in hypercholesterolemia and of the usefulness of therapies designed to normalize HDL
• It consisted of:
  • An international state-of-the-art forum with the most renowned key opinion leaders delivering most recent knowledge in the field
  • The creation of a set of video interviews of the speakers invited to this forum
  • The production of an article signed by every speaker in a leading peer-reviewed cardiovascular journal (work in progress)
  • Securing the necessary grants to implement the program

Results

• Enthusiastic leading speakers
• Education program on TMA website (work in progress)
• Publication of a lead article (work in progress)

Discuss current advances in HDL science, including limitations of HDL as a biomarker, HDL dysfunction, and genetic associations of HDL lipoproteins with atherosclerotic cardiovascular disease.
• Review clinical trial data in HDL genetics and therapeutic targets, such as CETP.
• Apply pharmacogenomics as a strategy for targeting HDL therapeutics, as well as their potential role in the treatment framework.